At DESY Zeuthen scientists of the NIC Group and the Computer Center provide support for large-scale numerical simulations in Lattice QCD on HPC systems. This includes the development of application-specific software or hardware solutions and the operation of services and computing infrastructure. Examples are contributions to the development of energy efficient parallel computer architectures (APE and QPACE). operation of the LDG Metadata Catalogue, or coordination and data management for large-scale lattice simulations, like CLS.